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Improvement of Prostate Cancer Aggressiveness Prediction Based on the Deep Learning Model Using Size Normalization and Multiple Loss Functions on Multi-parametric MR Images
Yoon Jo Kim, Julip Jung, Sung Il Hwang, Helen Hong
http://doi.org/10.5626/JOK.2023.50.10.866
Prostate cancer is the second most common cancer in men worldwide, and it is essential to predict the aggressiveness of prostate cancer because the recurrence rate and the effectiveness of treatment vary depending on the aggressiveness. This study enhances the information on small tumors by applying size normalization to predict the aggressiveness of prostate cancer in multi-parametric MR imaging. Additionally, we propose the use of multiple loss functions to distinguish tumors with different aggressiveness while having a similar visual appearance. Experimental results show that the proposed model trained with size-normalized ADC maps achieves an accuracy of 76.28%, sensitivity of 76.81%, specificity of 75.86%, and an AUC of 0.77. Moreover, compared to the tumor-centered ADC maps, size-normalized ADC maps demonstrate improved performance in tumors smaller than 1.5 cm, with an accuracy of 76.47%, sensitivity of 90.91%, and specificity of 69.57%, corresponding to a significant improvement of 17.65%, 27.27%, and 13.05% respectively.
Automatic Segmentation of Lung Cancer in Chest CT Images through Capsule Network-based Dual-Window Ensemble Learning
Jumin Lee, Julip Jung, Helen Hong, Bong-Seog Kim
http://doi.org/10.5626/JOK.2021.48.8.905
It is difficult to accurately segment lung cancer in chest CT images when it has an irregular shape or nearby structures have a similar intensity as lung cancer. In this study, we proposed a dual window ensemble network that uses a capsule network to learn the relationship between lung cancer and nearby structures and additionally considers the mediastinal window image with the lung window image to distinguish lung cancer from the nearby structures. First, intensity and spacing normalization was performed on the input images of the lung window setting and mediastinal window setting. Second, two types of 2D capsule network were performed with the lung and mediastinal setting images. Third, the final segmentation mask was generated by ensemble the probability maps of the lung and mediastinal window images through average voting by reflecting the weight based on the characteristics of each image. The proposed method showed a Dice similarity coefficient(DSC) of 75.98% which was 0.53% higher than the method not considering the weight of each window setting. Furthermore, segmentation accuracy was improved even when lung cancer was surrounded by nearby structures.
Tumor Motion Tracking during Radiation Treatment using Image Registration and Tumor Matching between Planning 4D MDCT and Treatment 4D CBCT
During image-guided radiation treatment of lung cancer patients, it is necessary to track the tumor motion because it can change during treatment as a consequence of respiratory motion and cardiac motion. In this paper, we propose a method for tracking the motion of the lung tumors based on the three-dimensional image information from planning 4D MDCT and treatment 4D CBCT images. First, to effectively track the tumor motion during treatment, the global motion of the tumor is estimated based on a tumor-specific motion model obtained from planning 4D MDCT images. Second, to increase the accuracy of the tumor motion tracking, the local motion of the tumor is estimated based on the structural information of the tumor from 4D CBCT images. To evaluate the performance of the proposed method, we estimated the tracking results of proposed method using digital phantom. The results show that the tumor localization error of local motion estimation is reduced by 45% as compared with that of global motion estimation.
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