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EnhPred: Deep Learning Model for Precise Prediction of Enhancer Positions

Jinseok Kim, Suyeon Wy, Jaebum Kim

http://doi.org/10.5626/JOK.2025.52.1.35

Enhancers are crucial regulatory elements that control gene expression in living organisms. Therefore, enhancer prediction is essential for a deeper understanding of gene regulation mechanisms. However, precise enhancer prediction is challenging due to their variable lengths and distant target genes. Existing artificial intelligence-based enhancer prediction methods often predict enhancers without identifying their boundaries accurately. In this study, we developed a new deep learning-based enhancer prediction method called EnhPred, which consisted of Convolutional Neural Networks (CNN) and bidirectional Gated Recurrent Units (GRU). To predict enhancer regions with a high resolution, we designed EnhPred to predict probabilities of enhancer presence within narrow segmented genomic regions. When evaluated with existing machine learning- and deep learning-based methods using data from three human cell lines, EnhPred demonstrated superior performances in terms of accuracy of enhancer prediction and resolution of enhancer boundaries.

AGB (Ancestral Genome Browser): A Web Interface for Browsing Reconstructed Ancestral Genomes

Daehwan Lee, Jongin Lee, Woon-Young Hong, Eunji Jang, Jaebum Kim

http://doi.org/

With the advancement of next-generation sequencing (NGS) technologies, various genome browsers have been introduced. Because existing browsers focus on comparison of the genomic data of extant species, however, there is a need for a genome browser for ancestral genomes and their evolution. In this paper, we introduce a genome browser, AGB (Ancestral Genome Browser), that displays ancestral genome data reconstructed from existing species. With AGB, it is possible to trace genomic variations that occurred during evolution in a simple and intuitive way. We explain the capability of AGB in terms of visualizing ancestral genomic information and evolutionary genomic variations. AGB is now available at http://bioinfo.konkuk.ac.kr/genomebrowser/.


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